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Contrary to most of the previous studies,89101112 our outcome definition also included suicide, a relevant outcome when assessing the safety of GLP-1 receptor agonists

This situation leads to neurodegeneration (cell death) in infarcted regions and global brain inflammation (Radak et al., 2017)

However, for patients with pre-existing gastrointestinal conditions such as gastroparesis (paralyzed stomach), severe gastroesophageal reflux disease (GERD), or inflammatory bowel disease (IBD), this mechanism can exacerbate symptoms

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